Bio-actives - a major focus of the recent developments in skincare. The most popular bioactive ingredients are enzymes, vitamins, antioxidants and various plant extracts, etc...
The most bio-active compound will work only if it penetrates the epidermis's outermost "horny" layer and reaches the living epidermis.
To better understand the penetration of active ingredients and product layering, we will look into the skin and pathways for epidermal penetration.
The skin has three main layers: epidermis, dermis, and subcutaneous tissue. And stratum corneum – the topmost layer of the epidermis represents the targeted surface.
Stratum corneum is a two-compartment system: dying or dead cells called corneocytes are embedded in an extracellular lipid matrix of highly nonpolar lipids like ceramides, cholesterol, and free fatty acids.
Because of its strategic location between the "horny" layers, this lipid matrix is known to act as a diffusion barrier for bio-actives entering the skin. It has a limited permeability for bio-actives is due to the nature and the tight packing of the stratum corneum's lipids.